Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Ixeris dentata (Thunb) Nakai attenuates cognitive impairment in MPTP-treated mouse model of Parkinson disease

Sung-Gyu Lee¹, Ki-Whan Kim², Hyun Kang¹

¹Department of Medical Laboratory Science, Dankook University, Cheonan-si, Chungnam, 31116; ²Department of R&D Center, C.L. Pharm Co., Ltd, #1603-5 Seoul Forest IT Catsle, Gwangnaru-ro 132-gil, Seongdong-gu, Seoul, 04788, Republic of Korea.

For correspondence:- Hyun Kang Email: hkang@dankook.ac.kr Tel:+82415503015

Accepted: 30 November 2017 Published: 29 December 2017

Citation: Lee S, Kim K, Kang H. Ixeris dentata (Thunb) Nakai attenuates cognitive impairment in MPTP-treated mouse model of Parkinson disease. Trop J Pharm Res 2017; 16(12):2911-2918 doi: 10.4314/tjpr.v16i12.15

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the cognition-enhancing effect of Ixeris dentata (Thunb) Nakai in a mouse model of Parkinson's disease (PD).

Methods: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced mouse model of PD was used to evaluate the effect of Ixeris dentata (IDE) extract on the alteration of behavioral responses using rota-rod and passive avoidance tests. The effect of IDE on oxidative stress levels were analyzed based on superoxide dismutase (SOD) and catalase (CAT) enzyme levels, and lipid peroxidation (LPO) in brain tissues.

Results: MPTP (20 mg/kg, ip)-induced mice resulted in a significant (p < 0.01) behavioral deficiencies in locomotor behavior (from 53.15 ± 1.01 to 23.56 ± 1.04) and cognitive functions (from 297 ± 2.47 to 201.17 ± 3.23 s) compared with their respective control groups. Administration of IDE (20, 40 and 80 mg/kg, po) for three weeks significantly and dose-dependently improved (p < 0.001 at 80 mg/kg) locomotor and cognitive deficits in MPTP- treated mice. IDE treatment also significantly (p < 0.01 at 80 mg/kg) inhibited decrease in superoxide dismutase and catalase enzyme activities, and lipid peroxides in MPTP-treated mice in brain tissues.

Conclusion: IDE exhibits good protection against MPTP-induced behavioral deficits via potential antioxidant defense mechanisms. Therefore, IDE could potentially be developed as a therapeutic approach for the treatment of neurodegenerative diseases

Keywords: Ixeris dentata, Neurodegenerative disease, MPTP, Parkinson's disease, Oxidative stress